FRI-2G.104-1-HC-03
APPLICATION OF HYPERBARIC OXYGENATION IN THE TREATMENT OF DIABETIC FOOT
Abstract
The mechanism of action of hyperbaric oxygenation is based on the fact that hyperbaric oxygen is a very powerful drug. There are data on the application of hyperbaric therapy as early as the end of the seventeenth century. Hyperbaric oxygen was first successfully used to treat decompression sickness in 1937 by Behnke and Shaw.
Tissue oxygen pressure increases in accordance with arterial oxygen pressure. Oxygen under pressure dissolves in plasma, which increases the partial pressure of arterial oxygen. The huge amount of dissolved oxygen eliminates the need for erythrocytes for oxygenation
Diabetic foot ulcers affect about 15% of patients with diabetes mellitus and are the leading cause of non-traumatic lower limb amputations. They are most often located on the plantar surfaces, as they bear the weight of the body. The pathological condition of delayed healing of these wounds is associated with tissue ischemia and prolonged oxygen deficiency
Tissue oxygen pressure increases in accordance with arterial oxygen pressure. Oxygen under pressure dissolves in plasma, which increases the partial pressure of arterial oxygen. The huge amount of dissolved oxygen eliminates the need for erythrocytes for oxygenation
Diabetic foot ulcers affect about 15% of patients with diabetes mellitus and are the leading cause of non-traumatic lower limb amputations. They are most often located on the plantar surfaces, as they bear the weight of the body. The pathological condition of delayed healing of these wounds is associated with tissue ischemia and prolonged oxygen deficiency
Keywords
Hyperbaric oxygen, Hyperbaric oxygenation, Diabetes mellitus, Diabetic foot, Oxygen deficiency
REFERENCES
- Boremia, I., Meyne, NG., Brummelkamp, WH., Bouma, S., Mensch, MH., Kamermans, F., Stern Hanf, M., van Alderen, A. (1960). Life without blood. Ned Tijdschr Geneeskd. 1960 May 7;104:949-54. Dutch. PMID: 13802034.
- Ennis, WJ., Huang, ET., Gordon, H. (2018) Impact of Hyperbaric Oxygen on More Advanced Wagner Grades 3 and 4 Diabetic Foot Ulcers: Matching Therapy to Specific Wound Conditions. Adv Wound Care (New Rochelle). 2018 Dec 1;7(12):397-407. doi: 10.1089/wound.2018.0855. Epub 2018 Dec 20. PMID: 30671282; PMCID: PMC6338555.
- Grainge, C. (2004). Breath of life: the evolution of oxygen therapy. J R Soc Med. 2004 Oct;97(10):489-93. doi: 10.1177/0141076809701011. PMID: 15459264; PMCID: PMC1079621.
- Grover, I., Neuman, T. (2006) Hyperbaric oxygen therapy, Editor(s): Geoffrey J. Laurent, Steven D. Shapiro, Encyclopedia of Respiratory Medicine, Academic Press, 2006, Pages 292-296, ISBN 9780123708793. URL: https://doi.org/10.1016/B0-12-370879-6/00180-0. (Accessed on 11.03.2024)
- Hancock, JT. (2022) A Brief History of Oxygen: 250 Years on. Oxygen. 2022; 2(1):31-39. URL: https://doi.org/10.3390/oxygen2010004 (Accessed on 11.03.2024)
- Hanley, ME., Manna, B. (2024) Hyperbaric Treatment of Diabetic Foot Ulcer. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: URL: https://www.ncbi.nlm.nih.gov/books/NBK430783/ (Accessed on 12.03.2024)
- Hong, S., Pouya, S., Suvi, K., Moritz, P., Katherine, O., Bruce, B. D., Caroline, S., Abdul, B., Juliana, C.N. C., Jean, C.M., Meda, E. P., Ambady, R., Sarah, H.W, Steven, J., William, H. H., Ping, Z., Christian, B., Shihchen, K., Edward, J. B., Dianna, J. M. (2022) IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045, Diabetes Research and Clinical Practice, Volume 183, 2022, 109119, ISSN 0168-8227, https://doi.org/10.1016/j.diabres.2021.109119.(https://www.sciencedirect.com/science/article/pii/S0 168822721004782) (Accessed on 02.09.2024)
- Jagannathan, V., & Viswanathan, P. (2022). Hyperbaric oxygen therapy and chemokine administration - a combination with potential therapeutic value for treating diabetic wounds. World Journal of Diabetes. 13. 1122-1130. 10.4239/wjd.v13.i12.1122.
- Kindwall, E.P. (1995) Hyperbaric Medicine Practice. 2nd ed. Best Publishing Company; Flagstaff, AZ, USA: 1995. A History of Hyperbaric Medicine; pp. 2-15.
- Lam, G., Fontaine, R., Ross, FL., Chiu, ES. (2017) Hyperbaric Oxygen Therapy: Exploring the Clinical Evidence. Advances in Skin & Wound Care 30(4):pр. 181-190, April 2017. | DOI: 10.1097/01.ASW.0000513089.75457.22.
- Mathieu, D., Marroni, A., Kot, J. (2017). Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment. Diving and hyperbaric medicine. 47. 24-32., https://www.researchgate.net/publication/320872017 (Accessed on 02.10.2024)
- Ortega, MA., Fraile-Martinez, O., García-Montero, C., Callejón-Peláez E., Sáez, MA., Álvarez- Mon, MA., García-Honduvilla, N., Monserrat, J., Álvarez-Mon, M., Bujan, J., Canals, ML. (2021) A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities. Medicina (Kaunas). 2021 Aug 24;57(9):864. doi: 10.3390/medicina57090864. PMID: 34577787; PMCID: PMC8465921.
- Rui, L., Ling, L., M., Guenther, B., Gangyi, Y. (2013). Systematic Review of the Effectiveness of Hyperbaric Oxygenation Therapy in the Management of Chronic Diabetic Foot Ulcers. Mayo Clinic Proceedings, Volume 88, Issue 2, 2013, Pages 166-175, ISSN 0025-6196, https://doi.org/10.1016/j.mayocp.2012.10.021.(https://www.sciencedirect.com/science/article/pii/S0 025619612011238) (Accessed on 02.10.2024)
- Second European Consensus Document on chronic critical leg ischemia. Circulation. (1991) Nov;84(4 Suppl):IV1-26. PMID: 1834364., https://pubmed.ncbi.nlm.nih.gov/1834364/ (Accessed on 12.10.2024)
- Sen, S., Sen, Sh. (2021). Therapeutic effects of hyperbaric oxygen: integrated review. Medical Gas Research 11(1):p 30-33, Jan-Mar 2021. | DOI: 10.4103/2045-9912.310057.
- Smolle, C., Lindenmann, J., Kamolz, L., Smolle-Juettner, F.-M. (2004) The History and Development of Hyperbaric Oxygenation (HBO) in Thermal Burn Injury. Medicina 2021, 57, 49. https://doi.org/10.3390/medicina57010049.
- Tao L, Yuan X. (2024). Efficacy and safety of hyperbaric oxygen therapy in the management of diabetic foot ulcers: A systematic review and meta-analysis. Int Wound J. 2024; 21(3):e14507. doi:10.1111/iwj.14507; https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.14507 (Accessed on 02.10.2024)
- Zhiming, Z., Wenjing, Z., Yuqi, X., Dewu, L. (2016). Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis, Asian Journal of Surgery, Volume 45, Issue 1, 2022, Pages 68-78, ISSN 1015-9584, https://doi.org/10.1016/j.asjsur.2021.07.047.(https://www.sciencedirect.com/science/article/pii/S10 15958421004644) (Accessed on 02.10.2024)
- URL:https://www.idtechex.com/en/research-article/advanced-wound-care-technologies-to-manage-wound-infections/15482 (Accessed on 12.03.2024)
- URL:https://www.lekar.bg/867/12 (Accessed on 12.03.2024)