UNIVERSITY OF RUSE "ANGEL KANCHEV"
UNION OF SCIENTISTS - RUSE

Proceedings 2024
Faculty of Public Health and Health CareBook 8.3 · Health Care

FRI-2G.104-1-HC-04

LATENT AUTOIMMUNE DIABETES IN ADULTS (LADA)

Language: BGPages: 26-31

Cite this paper

Assist. Yuliya Slavova

Department of Health Care University of Ruse “Angel Kanchev”

ORCID: 0009-0005-9000-2361

E-mail: ypslavova@uni-ruse.bg

Abstract

Latent Autoimmune Diabetes in Adults (LADA) is a type of diabetes characterized by the dysfunction or destruction of pancreatic β cells in the early stages, without the need for insulin treatment. In LADA differs from both classic type 1 diabetes (T1D) and type 2 diabetes (T2D) in several aspects, such as genetic background, immune response, rate of decline in pancreatic function, and clinical metabolic features. The progression of the disease progression and drug response of patients with LADA are closely related to the level of islet autoimmunity, making it essential to study the underlying causes of LADA for better prevention and treatment. Previous research has shown that both adaptive and innate immune responses play a crucial role in clearance of LADA. More recent studies have also highlighted the role of the gut microbiota, which significantly influences the immune system, in the progression of LADA. Moreover, since the destruction of pancreatic β cells occurs more slowly in LADA compared to classic T1D, there is a larger window of opportunity for intervention. Therefore, treatments such as anti-diabetic drugs with immune-modulating effects and immunotherapies hold promise for LADA management. This report aims to emphasize the potential of targeting gut microbiota and gut-related immunity as a way to slow or halt the autoimmune process in LADA.

Keywords

adaptive immunity, gut-related immunity, immunotherapy, innate immunity, latent autoimmune diabetes in adults

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