Best Paper
THU-SSS-BFT(R)-01
STUDYING THE EFFECTS OF FOOD ADDITIVES ON THE HUMAN MICROBIOME - A REVIEW
Abstract
The human microbiome is essential to maintaining health, influencing digestion, immunity, and even neurological functions. Modern diets increasingly include food additives-substances added to enhance flavor, texture, preservation, and appearance. This review explores how exposure to food additives may impact the human microbiome. It first outlines the importance of the microbiome, then discusses the nature and types of food additives, and finally presents current studies on the interactions between additives and microbial communities. Understanding these effects is crucial for public health and dietary recommendations.
Keywords
Microbiome, Food additive, Health
REFERENCES
- Bachmann, A., Müller, B., Schubert, R. and Wendisch, V.F., (2023). Impact of food-grade antimicrobials on gut microbial xenobiotic metabolism. Microbial Biotechnology, 16(1), pp.78- 89.
- Belkaid, Y. and Hand, T.W., (2014). Role of the microbiota in immunity and inflammation. Cell, 157(1), pp.121-141.
- Bian, X., Chi, L., Gao, B., Tu, P., Ru, H. and Lu, K., (2017). The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS ONE, 12(6), p.e0178426.
- Chassaing, B. and Gewirtz, A.T., (2018). Has provoking microbiota aggression driven the obesity epidemic?. BioEssays, 40(1), p.1700252.
- Chassaing, B., Van de Wiele, T. and De Vos, W.M., (2023). Interactions of emulsifiers with the microbiome and their potential health impacts. Nature Reviews Gastroenterology & Hepatology, 20(3), pp.137-150.
- Chen, Y., Wu, X., Yin, Y. and Liang, Y., (2022). Synthetic food colorants and the gut microbiota: Impact and implications. Food and Chemical Toxicology, 168, p.113372.
- Garcia-Gonzalez, N., Prete, R., Battista, N. and Corsetti, A., (2019). The impact of nitrites on the gut microbiota and implications for health. Frontiers in Microbiology, 10, p.368.
- Inan-Eroglu, E. and Ayaz, A., (2019). Is the gut microbiota a new target for food safety evaluation?. Critical Reviews in Food Science and Nutrition, 59(18), pp.3067-3076.
- Ivanovic, S. and Dimitrijevic Brankovic, S., (2024). Gut microbiota alterations due to dietary emulsifiers: New insights and health implications. Nutrition Reviews, 82(1), pp.16-30.
- Jarmakiewicz-Czaja, S., Birk, M., Górka, P. and Wiącek, D., (2025). Impact of food preservatives on the composition and function of gut microbiota: An overview. International Journal of Food Sciences and Nutrition, 76(2), pp.103-116.
- Khalaf, H., Larsson, G. and Lönn, J., (2020). Tartrazine alters gut microbiota and microbial metabolic profiles in mice. Toxics, 8(4), p.111.
- Martinez-Medina, M., Aldeguer, X., Gonzalez-Huix, F., Acero, D. and Garcia-Gil, L.J., (2021). Emulsifiers and colitis: experimental evidence and underlying mechanisms. Gut Microbes, 13(1), p.1919995.
- Miremadi, F., Sherkat, F. and Stojanovska, L., (2020). Effects of food preservatives on gut microbiota: A systematic review. Trends in Food Science & Technology, 102, pp.230-243.
- Mwale, J., (2023). Food additives: Classifications, usage, and regulatory implications. Food Chemistry Advances, 2(1), p.100013.
- Naimi, S., Viennois, E., Gewirtz, A.T. and Chassaing, B., (2021). Direct impact of commonly used food additives on gut microbiota and host health. Scientific Reports, 11, p.11268.
- Narushima, S., Saito, Y., Ogura, Y., Nakayama, J. and Hattori, M., (2021). Preservatives and their interaction with beneficial microbes: Potassium sorbate and Lactobacillus. Microbiome Research Reports, 2(1), pp.41-50.
- Palmnas, M.S.A., Cowan, T.E., Bomhof, M.R., Su, J., Reimer, R.A., Vogel, H.J. and Shearer, J., (2014). Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in diet-induced obese rats. PLOS ONE, 9(10), p.e109841.
- Raoul, P., Cardin, C., Delteil, C. and Thomas, M., (2022). Ultra-processed food intake and gut microbiota: A comprehensive review. Nutrients, 14(4), p.865.
- Ridaura, V.K., Faith, J.J., Rey, F.E., Cheng, J., Duncan, A.E., Kau, A.L., Griffin, N.W., Lombard, V., Henrissat, B., Bain, J.R. and Muehlbauer, M.J., (2013). Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 341(6150), p.1241214.
- Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P.I., Godneva, A., Kalka, I.N., Bar, N. and Shilo, S., (2020). Environmental factors dominate over host genetics in shaping human gut microbiota composition. Nature, 555(7695), pp.210- 215.
- Round, J.L. and Mazmanian, S.K., (2009). The gut microbiota shapes intestinal immune responses during health and disease. Nature Reviews Immunology, 9(5), pp.313-323.
- Schrezenmeir, J. and de Vrese, M., (2020). Emulsifiers, gut microbiota and health: Revisiting the evidence. Clinical Nutrition, 39(7), pp.2344-2352.
- Sharma, R., Wadhwa, P. and Thakur, N., (2021). Food additives: Functional and health perspectives. Journal of Food Biochemistry, 45(6), p.e13759.
- Suez, J., Cohen, Y., Valdés-Mas, R., Mor, U., Dori-Bachash, M., Federici, S., Zmora, N., Leshem, A., Heinemann, M., Linevsky, R. and Rothschild, D., (2022). Personalized microbiome- driven effects of non-nutritive sweeteners on human glucose tolerance. Cell, 185(18), pp.3307- 3328.
- Trompette, A., Gollwitzer, E.S., Pattaroni, C. and Marsland, B.J., (2020). SCFA depletion and colonic inflammation from dietary emulsifiers in mice. Nature Communications, 11, p.3755.
- Valdes, A.M., Walter, J., Segal, E. and Spector, T.D., (2018). Role of the gut microbiota in nutrition and health. BMJ, 361, p.k2179.
- Viennois, E., Merlin, D. and Gewirtz, A.T., (2017). Dietary emulsifiers direct the gut microbiota to promote colitis and metabolic syndrome. Gut, 66(9), pp.1414-1427.
- Wang, J., Lu, Y., Wang, Y. and Zhang, L., (2020). Dietary preservatives and gut microbial balance: New insights from human and animal studies. Frontiers in Nutrition, 7, p.591814.
- Wang, Y., Zhang, X., Wang, L. and Duan, Y., (2024). The gut microbiome: A mediator between diet and chronic diseases. International Journal of Molecular Sciences, 25(1), p.345.
- Wu, F., Zhao, S., Yu, B., Chen, Y. and Wu, J., (2021). Food antimicrobials selectively inhibit beneficial gut bacteria: Implications for health. Journal of Agricultural and Food Chemistry, 69(12), pp.3672-3681.
- Zhao, L., Zhang, F. and Ding, X., (2023). Short-chain fatty acids and the microbiome: The role of dietary additives in gut health. Trends in Endocrinology & Metabolism, 34(3), pp.187- 200.
- Zhou, Y., Sun, Z. and Tang, H., (2023). Microbiome dysbiosis and chronic disease: Food additive interactions in focus. Nutrients, 15(9), p.1992.